本人研究方向为肿瘤靶向性纳米药物的功能化设计和合成,利用多功能聚合物纳米载体、黑磷放疗增敏剂以及功能化纳米硒用于肿瘤诊断及放疗增敏中的应用和机制探索。在博士后及研究生期间多次获得教育部港澳台侨奖学金特等奖,以第一作者发表在本领域重要期刊Adv. Funct. Mater. (IF:19.924),ACS Nano (IF:18.027,两篇),Nano research (IF:10.269) Int. J. Nanomed. (IF:7.033)和J. Mater. Chem. B (IF:6.331,两篇) 等发表论文9篇,总影响因子为98.100,h-index为15,论文总引737次, 并申报中国专利6项, 授权专利4项,获得国家自然科学基金青年项目、博士后科学基金,促进了纳米科学在生物医药领域的应用。
05/2022-至今, 珠海市人民医院,转化医学研究员,副研究员
07/2019-03/2022,暨南大学,医学部第一临床医院,博士后
09/2016-06/2019,暨南大学生命科学与技术学院,再生医学,博士
09/2013-06/2016,暨南大学药学院,药剂学,硕士
09/2009-06/2013,广东药科大学,药物制剂,学士
1.国家自然科学基金青年项目:磷基复合材料抑制PLK1激酶介导肿瘤细胞G2/M期阻滞高效增敏放疗,30万(22205079,2023/1-2025/12),项目主持人;
2.中国博士后科学基金面上项目:黑磷钆复合材料用于X射线触发的肿瘤精准诊断和治疗,8万元(2019M663365,2020/1-2021/12),项目主持人;
3.国家自然科学基金,面上项目,硒代胱氨酸衍生物调控硒蛋白干预肿瘤多模态治疗的分子机制研究, 58万(32171296,2022/01-2025/12),项目参与人;
4.万人计划青年拔尖人才项目:肿瘤靶向纳米药物的化学设计,160万(W02070191,2018/01-2022/12),项目参与人;
5.国家自然科学基金面上项目:含硒金属配合物的靶向设计与抗肿瘤作用机制研究,67万(21877049,2019/01/01-2022/12/31),项目参与人;
6.广东省基础与应用基础研究基金区域联合基金重点项目:基于功能化纳米硒的肿瘤放射免疫治疗新策略及其临床转化应用(2020B1515120043,2020/10-2023/09),100万,项目参与人。
1 | Leung Chan#, Yongkang Liu#, Muhe Chen#, Yanhong Su, Junxian Guo, Liwen Zhu, Meixiao Zhan, Tianfeng Chen*, Ligong Lu*. Cuproptosis-Driven Enhancement of Thermotherapy by Sequentially Response Cu2-xSe viaCopper Chemical Transition, Adv. Funct. Mater. 2023, DOI: 10.1002/adfm.202302054. | 19.924 A1-1区 |
2 | Leung Chan, Pan Gao, Wenhua Zhou, Chaoming Mei, Yanyu Huang, Xue-Feng Yu*, Paul K. Chu, Tianfeng Chen*. Sequentially Triggered Delivery System of Black Phosphorus Quantum Dots with Surface Charge-Switching Ability for Precise Tumor Radiosensitization. ACS Nano, 2018, 12(12): 12401-12415. | 18.027 A1-1区 |
3 | Leung Chan#, Xiaodan Chen#, Pan Gao, Jun Xie Zhongyang Zhang, Jianfu Zhao, Tianfeng Chen*. Coordination-Driven Enhancement of Radiosensitization by Black Phosphorus via Regulating Tumor Metabolism. ACS Nano, 2021, 15(2): 3047-3060. | 18.027 A1-1区 |
4 | Liwen Zhu#, Leung Chan#, Junping Wang#, Mingkai Chen, Fei Cai, Yuan Tian, Li Ma*, Tianfeng Chen*. Selenium-engineered bottom-up-synthesized lanthanide coordination nanoframeworks as efficiency X-ray-responsive radiosensitizers, Nano Research, 2022, 1-7. | 10.269 A1-1区 |
5 | Xiaoyuan Sha#, Leung Chan#, Xiaoyi Fan, Penghao Guo, Tianfeng Chen*, Lian Liu*, Jingxiang Zhong*. Thermosensitive Tri-Block Polymer Nanoparticle-Hydrogel Composites as Payloads of Natamycin for Antifungal Therapy Against Fusarium Solani.Int. J. Nanomed., 2022, 17: 1463–1478. | 7.033 A1-2区 |
6 | Leung Chan, Yanyu Huang, Tianfeng Chen*.Cancer-targeted Tri-block Copolymer Nanoparticles as Payloads of Metal Complexes to Achieve Enhanced Cancer Theranosis. J. Mater. Chem. B, 2016, 4(26): 4517-4525. | 7.571 A1-2区 |
7 | Zeyu Xiao#, Leung Chan#, Dong Zhang#, Cuiqing Huang, Chaoming Mei, Peng Gao, Yanyu Huang, Jianye Liang, Lizhen He, Changzheng Shi*, Tianfeng Chen*, Liangping Luo*. Precise Delivery of a Multifunctional Nanosystem for MR-guided Cancer Therapy and Monitoring of Tumor Response by Functional Diffusion-weighted MRI. Journal of Materials Chemistry B, 2019, 7(18): 2926-2937. | 7.571 A1-2区 |
8 | Leung Chan, Lizhen He, Binwei Zhou, Shouhai Guan, Mingjun Bo, Yahui Yang, Ying Liu, Xiao Liu, Yanyang Zhang, Qiang Xie*, Tianfeng Chen*. Cancer-targeted Selenium Nanoparticles Sensitize Cancer Cells to Continuous γ Radiation to Achieve Synergetic Chemo-radiotherapy. Chem-Asian J. 2017, 12(23): 3053-3060. | 4.839 A1-2区 |
9 | Zhou Liu#, Leung Chan#, Liyan Chen, Yan Bai*, Tianfeng Chen*. Facile Fabrication of Near-Infrared-Responsive and Chitosan-Functionalized Cu2Se Nanoparticles for Cancer Photothermal Therapy. Chem-Asian J. 2016, 11(21): 3032-3039. | 4.839 A1-2区 |
1.陈填烽(导师),陈樑. 一种靶向铱(III)配合物修饰黑磷复合物及其制备方法和应用,201811339045.(已授权)。
2.陈填烽(导师),陈樑. 一种聚合物负载天然右旋龙脑纳米粒子及其制备方法和应用,201811352654.5(已授权)。
3.陈填烽(导师),陈樑. 多糖功能化纳米硒在富硒水稻种植中的应用,201811325424.X。
4.罗良平,陈填烽,史长征,肖泽宇,陈樑,张东. 一种磁共振成像纳米药物载体、纳米载药系统及其制备方法,CN107715121B(已授权)。
5.陈填烽,罗良平,史长征,高鹏,陈樑. 一种磁共振成像纳米载体、纳米载药系统及其制备方法,201810117789.7(已授权)。
6.李晓玲,陈樑,陈填烽. 一种藻蓝蛋白的酶解方法及其应用,2020101100231870.4。
1.2022年,科技创新发展先进个人奖;
2.2019年,学术创新成果奖;
3.2018年,学术创新成果奖;
4.2016年,广东第六届大学生材料创新大赛,获得三等奖;
5.2016年,第六届国际硒研讨会(The 6th International Selenium Conference)墙报展示,获“Best Wall Newspaper”称号;