简介

    本人主要从事硒/碲基药物的设计合成及其在肿瘤治疗、抗氧化、免疫系统调控等方面的应用机制研究。目前已以第一作者和共同第一作者身份在Matter (Cell press) (IF=19.967), Adv Func Mater (IF=19.924), ACS Nano (IF=18.027), Bioact Mater (IF=16.874), ACS Appl Mater Interfaces J (IF=10.383), 和Chemical Communications（IF=6.222）和等杂志发表学术论文11篇，其中SCI一区、影响因子10分以上的学术论文7篇。先后获得了国家自然科学基金青年基金、广东省区域联合基金-青年基金项目和暨南大学华侨医院博士后启动基金的资助。参与申报中国专利4项，授权专利1项。推进了碲基药物在生物医药领域的应用研究。

教育背景

2020/11-至今，  暨南大学，医学部第一临床医院，博士后，助理研究员

2017/09-2020/07，暨南大学生命科学与技术学院，生物化学与分子生物学，博士

2014/09-2017/07，暨南大学化学与材料学院，无机化学，硕士

2010/09-2014/07，江西师范大学，材料化学，学士

发表论文

1. Wei Huang, Lizhen He, Jiang Ouyang, Qi Chen, Chuang Liu, Wei Tao*, and Tianfeng Chen*. Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy. Matter (Cell Press), 2020, 3(5): 1725-1753. (IF=19.967)

2. Wei Huang, Lizhen He*, Zhongyang Zhang, Sujiang Shi, Tianfeng Chen*, Shape-Controllable Tellurium-Driven Heterostructures with Activated Robust Immunomodulatory Potential for Highly Efficient Radiophotothermal Therapy of Colon Cancer, ACS Nano, 2021, 15(12): 20225-20241. (IF=18.027)

3. Wei Huang, Sujiang Shi, Haoran Lv, Zhenyu Ju, Qinghua Liu*, Tianfeng Chen*; Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer, Bioactive Materials, 2023, BIOACTMAT-D-23-00277. (IF=16.874)

4. Wei Huang, Yanyu Huang, Yuanyuan You, Tianqi Nie, Tianfeng Chen*. High-yield synthesis of multifunctional tellurium nanorods to achieve simultaneous chemophotothermal combination cancer therapy. Advanced Functional Materials, 2017, 27(33), 1701388. 封面文章 (IF=19.924)

5. Fengzhi Zhao¹, Wei Huang¹, Lizhen He, Shiqing Nie, Zhiting Sun, Tianfeng Chen^⁎,Haiyan Yin^⁎, Jianfu Zhao^⁎ Reversing lung cancer radioresistance by hyperpermeable tellurium nanotherapeutics via remodeling tumor microenvironment. Nano Today, 2023, 50, 101819. (IF=18.962)

6. Jing Huang⁺, Wei Huang⁺, Zehang Zhang, Xueran Lin, Hao Lin, Lijiao Peng*, and Tianfeng Chen*. Highly Uniform Synthesis of Selenium Nanoparticles with EGFR Targeting and Tumor Microenvironment Responsive Ability for Simultaneous Diagnosis and Therapy of Nasopharyngeal Carcinoma. ACS Applied Materials&Interfaces, 2019, 11, 11177-11193. (IF=10.383)

7. Shaolie Zheng+, Wei Huang+, Nan Li, Yuan Shen, Xiaoyu Wang*, Tianfeng Chen*. Highly specific selenium nanosystems for fluorescent image-guided rapid diagnosis and pathological grading of ovarian malignant tumors. Chinese Chemical Letters, 2023, 34, 107764. (IF=8.455)

8. Wei Huang, Yuanwei Liang, Chengcheng Sang, Chaoming Mei, Xiaoling Li*, Tianfeng Chen*. Therapeutic Nanosystems Co-deliver Anticancer Drugs and Oncogene SiRNA to Achieve Synergetic Precise Cancer Chemo-gene Therapy. Journal of Materials Chemistry B, 2018, 6(19): 3013-3022. (IF=7.571)

9. Liyuan Hou^‡, Wei Huang^‡, Jiaqi Cheng, Xuanru Deng, Haoqiang Lai, Zhen Chen, Zepang Zhan, Pengju Feng*, Yiqun Li*, Fang Yang*, Tianfeng Chen. The investigation and bioorthogonal anticancer activity enhancement of a triphenylphosphine-labile prodrug of seleno-combretastatin-4. Chemical Communications, 2020, 56(92): 14495-14498. (IF=6.065)

10. Wei Huang^‡, Zhen Chen^‡, Liyuan Hou, Pengju Feng*, Yiqun Li* and Tianfeng Chen, Adjusting the lipid-water distribution coefficient of iridium(III) complexes to enhance the cellular penetration and treatment efficacy to antagonize cisplatin resistance in cervical cancer. Dalton Transactions, 2020, 49(33): 11556-11564.  (IF=4.569)

11. Wei Huang⁺, Hualian Wu⁺, Xiaoling Li,* and Tianfeng Chen*, Facile one-pot synthesis of tellurium nanorods as antioxidant and anticancer agents. Chemistry-An Asian Journal, 2016, 11(16): 2301-2311. (IF=4.839)

科研项目

1. 国家自然科学基金，国家自然科学基金青年科学基金项目，单元素碲调控硒蛋白增强肿瘤放射治疗的分子机制研究，2023-01至 2025-12，30万元，主持；

2. 广东省科学技术厅, 区域联合基金-青年基金项目, 一种普适性合成贵金属-碲基半导体异质结的方法及其用于增敏肿瘤放射治疗的作用机制研究, 2021-10至 2024-09, 10万元, 主持。

专利

1. 陈填烽，郭晓明，黄炜，陈樑，彭发，一种可食用纳米碳酸钙-维生素D3颗粒及其制备方法，专利号：201910933010.3. （已授权）

2. 陈填烽，王晓玉，郑少烈，黄炜，双重靶向纳米硒复合材料在恶性肿瘤术中显影的应用，申请号：2021113433805.

3. 陈填烽，王晓玉，郑少烈，黄炜，双靶向纳米硒-阿霉素复合物在铂耐药恶性肿瘤治疗的应用，申请号：2021113433773.

4. 陈填烽，许利耕，黄炜，施肃江，蒋亚琳，基于纳米碳酸锰或掺杂碳酸锰递送系统的纳米疫苗及制备方法与应用，申请号：202211267081.2

获奖情况

1. 2020年，暨南大学“优秀毕业生”称号

2. 2019年，暨南大学“科研之星”称号

3. 2018年，国家奖学金

4. 2017年，傅家谟院士奖励金优秀奖

5. 2016年，暨南大学2016年瑞沃德基础医学明德奖学金

6. 2016年，广东省第六届材料创新大赛总决赛二等奖