教育背景

2018/09-至今, 暨南大学, 无机化学, 硕博

2010/09-2014/06, 东华理工大学大学, 应用化学, 学士

科研项目

暨南大学博士研究生拔尖创新人才培养项目，2022CXB008，TrxR 特异性靶向含硒金属配合物放疗增敏剂的作用机理研究，2023-10-01至 2024-10-01,2万元, 在研, 主持

发表论文

(1)     Mingkai Chen^†, Wenqiang Cao^†, Junping Wang^†, Fei Cai, Liwen Zhu, Li Ma*, Tianfeng Chen*. Selenium Atom-Polarization Effect Determines TrxR Specific Recognition of Metallodrugs, J. Am. Chem. Soc. 2022, 144: 20825-20833.

(2)     Yuequn Zhang^†, Mingkai Chen^†, Junping Wang, Fei Cai, Li Ma*, Tianfeng Chen*. Atom Engineering-Regulated In Situ Transition of Cu(I)-Cu(II) for Efficient Overcoming Cancer Drug Resistance, Sci. China Chem. 2022, 65: 1879-1884.

(3)     Fei Cai,^a,†Kun Ye,^a,†Mingkai Chen,^a,†Yuan Tian,^a Peicong Chen,^b Hao Lin,^b,* Tianfeng Chen,^a Li Ma^a,* High-dimensional zinc porphyrin nanoframewroks as efficient radiosensitizers for cervical cancer, Chin. Chem. Lett. 2022: 107945.

(4)     Mingkai Chen^#, Xiaoting Huang^#, Huatian Shi, Jie Lai, Li Ma*, Tai-Chu Lau*, Tianfeng Chen*.Cr (V)–Cr (III) in-situ transition promotes ROS generation to achieve efficient cancer therapy. Biomaterials 2021, 276: 120991.

(5)     Mingkai Chen^#, Xiaoting Huang^#, Jie Lai, Li Ma*, Tianfeng Chen*. Substituent-regulated highly X-ray sensitive Os (VI) nitrido complex for low-toxicity radiotherapy. Chin. Chem. Lett. 2021, 32: 158-161.   

(6)     Yinghua Li, Danyang Chen, Jingyao Su, Mingkai Chen, Tianfeng Chen, Wei Jia, and Bing Zhu. Selenium-ruthenium complex blocks H1N1 influenza virus-induced cell damage by activating GPx1/TrxR1. Theranostics, 2023, 13: 1843.

(7)     Yahui Yang , Yalin Jiang , Bin Xie , Sujiang Shi , Fen Pi , Mingkai Chen , Chengcheng Sang , Ligeng Xu * and Tianfeng Chen. Selenadiazole derivative-loaded metal azolate frameworks facilitate NK cell immunotherapy by sensitizing tumor cells and shaping immuno-suppressive microenvironments. Biomaterials Science, 2023.

(8)     Liwen Zhu^§, Leung Chan^§, Junping Wang^§, Mingkai Chen, Fei Cai,Yuan Tian, LiMa*, Tianfeng Chen* Selenium-EngineeredBottom-up-SynthesizedLanthanideCoordinationNanoframeworksasEfficiencyX-ray-Responsive Radiosensitizers, Nano Rse., 2022: 1-7..

(9)     Jiang Ouyang, Qingyue Bu , Na Tao , Mingkai Chen, Haijun Liu, Jun Zhou, Jinggong Liu, Bo Deng,Na Kong, Xingcai Zhang , Tianfeng Chen*, Yihai Cao, Wei Tao*. A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms. Bioact. Mater. 2022,18: 446-458.