教育背景

07/2020–至今，博士后，暨南大学第一临床医学院，肿瘤学

09/2017–06/2020，博士，暨南大学，生物医药

09/2011–06/2014，硕士，暨南大学，生物化学与分子生物学

09/2011–06/2007，学士，广东药科大学，生物制药

发表论文

1.  Haoqiang Lai, Chang Liu, Liyuan Hou, Wenwei Lin, Tianfeng Chen* and An Hong*. TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of borneol on doxorubicin. Theranostics. 2020, 10, 22. (IF=8.036)

2.  Haoqiang Lai, Delong Zeng, Chang Liu, Qi Zhang, Xuan Wang, Tianfeng Chen*. Selenium-containing ruthenium complex synergizes with natural killer cells to enhance immunotherapy against prostate cancer via activating TRAIL/ FasL signaling.  Biomaterials. 2019, 219, 119377. (IF=10.317)

3.  Chang Liu,^‡Haoqiang Lai,^‡ and Tianfeng Chen* Boosting Natural killer cell-based cancer immunotherapy with selenocystine/transforming growth factor-beta inhibitor encapsulated nanoemulsion.  ACS Nano. 2020, DOI： 10.1021/acsnano.9b10103. (Co-first author, IF=14.588)

4.  Haoqiang Lai^‡, Xiaobin Zhang^‡, Zhenhuan Song, Zhongwen Yuan, Lizhen He^⁎, Tianfeng Chen^⁎. Facile synthesis of antioxidative nanotherapeutics using a microwave for efficient reversal of cisplatin-induced nephrotoxicity. Chemical Engineering Journal. 2020, 391,123563. (Co-first author, IF=10.652)

5.  Jinggong Liu,^†Haoqiang Lai,^† Zushuang Xiong, Bolai Chen and Tianfeng Chen. Functionalization and cancer-targeting design of ruthenium complexes for precise cancer therapy. Chemical Communication. 2019,55, 9094. (Co-first author, IF=6.12)

6.  Haoqiang Lai, Xiaoyan Fu, Chengcheng Sang, Liyuan Hou, Pengju Feng, Xiaoling Li,* and Tianfeng Chen*.Selenadiazole Derivatives Inhibit Angiogenesis-Mediated Human Breast Tumor Growth by Suppressing the VEGFR2-Mediated ERK and AKT Signaling Pathways. Chemistry-An Asian Journal.Chem. Asian J. 2018, 13, 1447 – 1457. (Co-first author)

7.  Haoqiang Lai, Xiang Zhang, Lina Xie, Jinjin Chen, Tianfeng Chen*. Enhancement of Antiangiogenic Efficacy of Iron(II) complex by Selenium Substitution. Chemistry-An Asian Journal, 2017, Chem. Asian J. 2017, 12, 982 – 987. (Cover)

8.  Lai Haoqiang‡, Zhao Z‡, Li L, Zheng W and Chen T* Antiangiogenic ruthenium(II) benzimidazole complexes, structure-based activation of distinct signaling pathways. Metallomics, 2015, 7(3), 439-447.(Co-first author, Front Cover)

9.  Su J1*#, Lai Haoqiang#, Chen1 J, Li L1, Wong YS, Chen T, Li X* Natural Borneol, a monoterpenoid compound, potentiates selenocystine induced apoptosis in human hepatocellular carcinoma cells by enhance-ment of cellular uptake and activation of ROS-mediated DNA damage. PloS one 2013,20;8(5):e63502. (Co-first author)

10.  Lizhen He, Haoqiang Lai, Tianfeng Chen. Dual-function nanosystem for synergetic cancer chemo-/radiotherapy through ROS-mediated signaling pathways. Biomaterials.2015, 51,30-42.

11.  Qiang xie, Lizhen He; Haoqiang Lai, Wenjie Zheng, Tianfeng Chen. Selenium substitution endows cystine with radiosensitization activity against cervical cancer cells. Biochemical and Biophysical Research Communications. 2014, 4, 34210-34216.

12.  Qiang Xie, Lizhen He, Haoqiang Lai, Wenjie Zheng, Tianfeng Chen*. Selenium substitution endows cystine the radiosensitization activity against cervical cancer cells. RSC Advances, 2014, 4 (64), 34210 - 34216.

13.  Lizhen He, Shengbin Ji, Haoqiang Lai and Tianfeng Chen*. Selenadiazole Derivatives as Theranostic Agents for Simultaneous Cancer Chemo-/Radiotherapy by Targeting Thioredoxin Reductase. J. Mater. Chem. B, 2015, 3, 8383 – 8393.

14. 赖浩强，袁日明，贺利贞，陈填烽.冰片及其纳米化制剂的生物医药应用进展. 药学进展，2019,43 (5):334-342.

科研项目

1.中国博士后科学基金：基于功能化纳米硒的脂类代谢调控在肿瘤免疫治疗中的应用研究，2020M681372，2020/11-2022/10，8万元，在研，主持；

2.国家高技术研究发展计划（863计划）项目，2014AA020538，肿瘤血管生成靶向性纳米硒设计与临床前评价，2014/01-2016/12，120万，已结题，主要成员。

专利发明

陈填烽，赖浩强. 右旋龙脑作为阿霉素增敏剂在制备抗肺癌药物中的应用，201811204466.8

获奖情况

1.中国教育部，研究生国家奖学金，2013.

2.中国教育部，研究生国家奖学金，2019.