陈 樑

职称:博士后 电话:
单位:暨南大学生命科学与技术学院 邮箱:330607059@qq.com

研究方向:肿瘤靶向性纳米创新药物

教育背景


07/2019至今,博士后,暨南大学第一临床医学院

09/2016–06/2019,博士(再生医学),暨南大学细胞系

09/2013–06/2016,硕士(药剂学),暨南大学药学院

09/2009–06/2013,学士(药物制剂),广东药科大学


研究方向


化学生物学:肿瘤靶向性纳米药物的设计与抗肿瘤活性

* 细胞生物学:细胞凋亡、细胞周期阻滞的信号转导通路

* 毒理学:药物的药代动力学及毒理学评价

* 影像学:核磁共振成像


发表论文


1. Leung Chan, Pan Gao, Wenhua Zhou, Chaoming Mei, Yanyu Huang, Xue-Feng Yu*, Paul K. Chu, Tianfeng Chen*. Sequentially Triggered Delivery System of Black Phosphorus Quantum Dots with Surface Charge-Switching Ability for Precise Tumor Radiosensitization. ACS Nano, 2018, 12: 12401-12415 (Featured Article).


2. Leung Chan, Yanyu Huang, Tianfeng Chen*. Cancer-targeted Tri-block Copolymer Nanoparticles as Payloads of Metal Complexes to Achieve Enhanced Cancer Theranosis. J. Mater. Chem. B, 2016, 4(26): 4517-4525.


3. Zeyu Xiao#, Leung Chan#, Dong Zhang#, Cuiqing Huang, Chaoming Mei, Peng Gao, Yanyu Huang, Jianye Liang, Lizhen He, Changzheng Shi*, Tianfeng Chen*, Liangping Luo*. Precise Delivery of a Multifunctional Nanosystem for MR-guided Cancer Therapy and Monitoring of Tumor Response by Functional Diffusion-weighted MRI. J. Mater. Chem. B, 2019.


4. Leung Chan, Lizhen He, Binwei Zhou, Shouhai Guan, Mingjun Bo, Yahui Yang, Ying Liu, Xiao Liu, Yanyang Zhang, Qiang Xie*, Tianfeng Chen*. Cancer-targeted Selenium Nanoparticles Sensitize Cancer Cells to Continuous γ Radiation to Achieve Synergetic Chemo-radiotherapy. Chem-Asian J. 2017, 12(23): 3053-3060.


5. Zhou Liu#, Leung Chan#, Liyan Chen, Yan Bai*, Tianfeng Chen*. Facile Fabrication of Near-Infrared-Responsive and Chitosan-Functionalized Cu2Se Nanoparticles for Cancer Photothermal Therapy. Chem-Asian J. 2016, 11(21): 3032-3039.


6. Zhou Liu, Leung Chan, Xiaoting Ye, Yan Bai*, Tianfeng Chen*. BSA-based Cu2Se Nanoparticles with Multistimuli-responsive Drug Vehicles for Synergistic Chemo-photothermal Therapy. Colloid Surface B, 2018, 172: 298-307.


7. Peng Gao, Chaoming Mei, Lizhen He, Zeyu Xiao, Leung Chan, Dong Zhang, Changzheng Shi*, Tianfeng Chen*, Liangping Luo*. Designing Multifunctional Cancer-targeted Nanosystem for Magnetic Resonance Molecular Imaging-guided Theranostics of Lung Cancer. Drug Deliv. 2018, 25(1): 1811-1825.


8. Xiaoling Li, Haobin Zhang, Leung Chan, Chang Liu, Tianfeng Chen*. Nutritionally Available Selenocysteine Derivative Antagonizes Cisplatin-Induced Toxicity in Renal Epithelial Cells through Inhibition of Reactive Oxygen Species-Mediated Signaling Pathways. J. Agr. Food Chem. 2018, 66(23): 5860-5870.


9. Yuanwei Liang, Wei Huang, Delong Zeng, Xiaoting Huang, Leung Chan, Chaoming Mei, Pengju Feng, Choon-Hong Tan*, Tianfeng Chen*. Cancer-targeted Design of Bioresponsive Prodrug with Enhanced Cellular Uptake to Achieve Precise Cancer Therapy. Drug Deliv. 2018, 25(1): 1350-1361.


10. Yahui Yang, Qiang Xie, Zhennan Zhao, Lizhen He, Leung Chan, Yingxiang Liu, Yongle Chen, Mingjun Bai, Tao Pan, Yanni Qu, Long Ling, Tianfeng Chen*. Functionalized Selenium Nanosystem as Radiation Sensitizer of 125I Seeds for Precise Cancer Therapy. Acs Appl. Mater. Inter. 2017, 9(31): 25857-25869.


11. Zhiqin Deng, Pan Gao, Lianling Yu, Bin Ma, Yuanyuan You, Leung Chan, Chaoming Mei, Tianfeng Chen*. Ruthenium Complexes with Phenylterpyridine Derivatives Target Cell Membrane and Trigger Death Receptors-Mediated Apoptosis in Cancer Cells. Biomaterials, 2017, 129: 111-126.


12. Yanyu Huang, Lizhen He, Zhenhuan Song, Leung Chan, Jintao He, Wei Huang, Binwei Zhou, Tianfeng Chen*. Phycocyanin-based Nanocarrier as a New Nanoplatform for Efficient Overcoming of Cancer Drug Resistance. J. Mater. Chem. B, 2017, 5, 3300- 3314.


13. Yanzhou Chang, Lizhen He, Zhibin Li, Lilan Zeng, Zhenhuan Song, Penghui Li, Leung Chan, Yuanyuan You, Xue-Feng Yu*, Paul K. Chu, Tianfeng Chen*. Designing Core−shell Gold and Selenium Nanocomposites for Cancer Radiochemotherapy. Acs Nano, 2017, 11(5): 4848-4858.


14. Hai Zhu, Binwei Zhou, Leung Chan, Tianfeng Chen*. Transferrin-functionalized Nanographene Oxide for Delivery of Platinum Complexes to Enhance Cancer-cell Selectivity and Apoptosis-inducing Efficacy. Int. J. Nanomed. 2017, 12: 5023.


15. Yanyu Huang, Wei Huang, Leung Chan, Binwei Zhou, Tianfeng Chen*. A Multifunctional DNA Origami as Carrier of Metal Complexes to Achieve Enhanced Tumoral Delivery and Nullified Systemic Toxicity. Biomaterials, 2016, 103:183-196.


16. Lilan Zeng, Jingjing Chen, Shengbin Ji, Leung Chan, Wenjie Zheng, Tianfeng Chen*. Construction of a Cancer-targeted Nanosystem as a Payload of Iron Complexes to Reverse Cancer Multidrug Resistance. J. Mater.

Chem. B, 2015, 3(21): 4345-4354.


获奖情况


  • 2018年教育部港澳台侨奖学金特等奖

  • 2018年学术创新成果奖

  • 2017年教育部港澳台侨奖学金特等奖

  • 2016年教育部港澳台侨奖学金特等奖

  • 2016年广东第六届大学生材料创新大赛三等奖

  • 2016年第六届国际硒研讨会(The 6th International Selenium Conference)墙报展示获“Best Wall Newspaper”称号