| 职称：教授 | 电话： |
| 单位：暨南大学化学与材料学院 | 邮箱： |
研究方向：药物化学与抗肿瘤药理
郑文杰博士，现任暨南大学化学系教授，博士生导师，研究方向为药物化学与抗肿瘤药理，主要集中于新型硒杂环化合物的分子设计与抗肿瘤活性评价、细胞凋亡、细胞周期阻滞的信号转导通路与基因调控，同时研究硒化合物作为常规化疗药物增敏剂的应用及机制。作为项目负责人共主持国家自然科学基金项目和教育部重点项目等10项。各项目进展顺利，并取得了相应的成果。在ACS Nano、InorganicChemistry、Dalton Transactions.和Biomaterials等本领域主流杂志共发表论文50篇，撰写专著一部（有机硒的化学及其医学应用），申报专利15项，其中已授权5项、成功转让一项。
1994年－1998年，博士研究生，中山大学化学与化学工程学院；
1982年－1985年，硕士研究生，中山大学化学与化学工程学院；
1978年－1982年，本科，中山大学化学与化学工程学院.
2011年-2015年，暨南大学研究生院执行院长；
1997年－至今，暨南大学化学系，教授；
1989年－1990年，访问学者，到香港大学潘宗光教授及支志明教授实验室从事科研合作；
2000.05～2003.10广东省学位与研究生学会副理事长兼秘书长；
2004.05～至今广东化工学会副理事长；
2003.07～至今广东省遗传学常务理事；
2001.05～至今广东省教育学会常务理事等；
主要著作：
1. 郑文杰，欧阳政．植物有机硒的化学及其医学应用．暨南大学出版社，2001，7．
2. 欧阳政，蔡端仁，郑文杰．生物体中硒的有机形态的分析研究．分析化学新进展，科学出版社（ISBN-7-03-010946-5），2002.11，510-516.
1. Wen Liu, Xiaoling Li, Yum-Shing Wong, Wenjie Zheng*, Yibo Zhang, Wenqiang Cao, Chen Tianfeng*. Selenium nanoparticles as a carrier of 5-Fluorouracil to achieve anticancer synergism. ACS Nano, 2012, 6 (8), 6578–6591.
2. Li Y, Li X, Wong YS, Chen Tianfeng*, Zhang H, Liu C, Wenjie Zheng*. The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials, 2011, 32, 9068-9076.
3. Shenggui Liu, Wenqiang Cao, Lianling Yu, Wenjie Zheng*, Linlin Li, Cundong Fan and Tianfeng Chen*. Zinc (II) Complexes Containing Bis-benzimidazole Derivatives as a New Class of Apoptosis Inducers That Trigger DNA damage-mediated P53 Phosphorylation in Cancer Cells.Dalton Transactions. 2013, 10.1039/C3DT33077J.
4. Chen Tianfeng, Yanan Liu, Wenjie Zheng, Jie Liu, Yum-Shing Wong. Ruthenium polypyridyl complexes target mitochondria and induce cancer cell apoptosis. Inorganic Chemistry. 2010, 49, 6366-6368.
5. Bo Yu, Yibo Zhang, Wenjie Zheng*, Cundong Fan, Tianfeng Chen*. Positive Surface Charge Enhances Selective Cellular Uptake and Anticancer Efficacy of Selenium Nanoparticles.Inogranic Chemistry. 2012, 51 (16), 8956–8963.
6. Linlin Li, Wenqiang Cao, Wenjie Zheng*, Cundong Fan and Tianfeng Chen*. Ruthenium Complexes Containing 2,6-bis(benzimidazolyl)pyridine derivatives Induce Cancer Cell Apoptosis by Triggering DNA Damage-mediated P53 Phosphorylation.Dalton Transactions. 2012, 41, 12766-12772.
7. Linlin Li, Yum-Shing Wong, Tianfeng Chen,* Cundong Fana and Wenjie Zheng*. Ruthenium Complexes Containing Bis-benzimidazole Derivatives as a New Class of Apoptosis Inducers. Dalton Transactions. 2012, 41 (4), 1138 – 1141.
8. Hualian Wu, Xiaoling Li, Wen Liu, Tianfeng Chen*, Yinghua Li, Wenjie Zheng and Ka-Hing Wong*. Surface decoration of selenium nanoparticles by mushroom polysaccharides-protein complexes to achieve enhanced cellular uptake and anticancer activity. Journal of Materials Chemistry, 2012, 22, 9602–9610.
9.Yibo Zhang, Xiaoling Li, Zhi Huang, Wenjie Zheng, Cundong Fan, Tianfeng Chen*. Enhancement of Cell Permeabilization and Apoptosis-inducing Activity of Selenium Nanoparticles by ATP Surface Decoration.Nanomedicine: Nanotechnology, Biology, and Medicine. 2013, 9, 74–84.
10. Chen Tianfeng, Zheng Wenjie *，Yang Fang，Bai Yan, Yum-Shing Wong. Accumulation of selenium in mixotrophic culture of Spirulina platensis on glucose. Bioresource Technology. 2006, 97, 2260-2265.
11. Zhang H#, Chen Tianfeng#, Jiang J, Wong YS, Yang F, Wenjie Zheng*. Selenium-containing allophycocyanin purified from selenium-enrich Spirulina platensis protects human erythrocytes from AAPH-induced oxidative damage through inhibition of ROS generation. Journal of Agricultural and Food Chemistry, 2011, 59, 8683-8690.
12. Chen Tianfeng, Yum-Shing Wong, Wenjie Zheng*, Jie Liu.Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. Chemico-Biological Interactions. 2009, 180, 54-60.
13. Chen Tianfeng, Zheng Wenjie*, Wong Yum-Shing, Yan Fang. Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative. Biomedicine & Pharmacotherapy. 2008, 62, 77-84.
14.Yi Luo, Xiaoling Li, Yum-Shing Wong, Tianfeng Chen*, Yibo Zhang, Wenjie Zheng*. 1,4-diselenophene-1,4-diketone induces caspase-dependent apoptosis in human A375 melanoma cells with involvement of mitochondrial dysfunction. Chem. Pharm. Bull., 2011, 59 (10), 1227-1232.
15.Chen Tianfeng, Wen-Jie Mei, Yum-Shing Wong, Jie Liu, Yanan Liu, Huang-Song Xie and WenJie Zheng*. Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers. Medicinal Chemistry Communications. 2010, 1, 73-75.
16.Jun-Sheng Zheng, Shan-Yuan Zheng, Yi-Bo Zhang, Bo Yu, Wenjie Zheng*, Fang Yang, Tianfeng Chen*. Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles. Colloids and Surfaces B: Biointerfaces. 2011, 83, 183-187.
17.Ya-Nan Liu, Tianfeng Chen, Wen-Jie Mei, Xiao-Mei Huang, Shuo Wu, Yum-Shing Wong, Jie Liu*, Wenjie Zheng*. DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3’)TPP - Ru(phen)2Cl]Cl and its heterometallic derivatives. Chemico-Biological Interactions. 2010, 183, 349-356.
18.Qian Li, Tianfeng Chen*, Fang Yang, Jie Liu, Wenjie Zheng*. Facile and controllable one-step fabrication of selenium nanoparticles assisted by L-cysteine. Materials Letters. 2010, 64, 614-617.
19.Bo Yu, Tianfeng Chen*, Fang Yang, Wen Liu, Ying-Hua Li and Wenjie Zheng*. Chitosan as Morphology-directing Agent for the Preparation of Multiarmed Selenium/Carbon Coaxial Nanorods. Chemistry Letters. 2011, 40, 242-243.
1.郑文杰，陈填烽，杨芳.具抗肿瘤活性的硒氮芳香杂环化合物及其制备方法与应用，CN 100497348，中国，已授权.
2.郑文杰，王自，白燕 ，张俊苓，杨芳，周艳晖. 液相氨基酸偶合的纳米单质硒及其制备和保存方法。(专利申请号：2007100270458).
3.郑文杰，王自，白燕 ，张俊苓，杨芳，周艳晖．液相维生素C复合的纳米单质硒及其制备与保存方法(专利申请号：200610132382.9).
4.郑文杰，杨芳，黄峙．活性蛋白复合型纳米硒的制备及液相保存技术(专利申请号：200510086601.x).
5.郑文杰，吴华莲，杨芳，刘杰,蔗糖分子偶和的纳米单质碲水溶胶的制备方法(专利申请号: 200810219521.0).
6.郑文杰、徐航、张逸波、陈填烽、杨芳、刘杰. 液相三磷酸腺苷耦合的纳米单质硒及其制备和保存方法(专利申请号：200910038320.5).
7.白燕，郑文杰，李维嘉，杨芳，黄峙, 液相多、聚糖纳米硒及其制备与保存. ZL200510086602.4. 中国，已授权.
8.白燕，王玉东，郑文杰，周艳晖.生物高聚物纳米硒复合膜的制备方法. ZL200610124279.X. 中国，已授权.
1.国家自然科学基金：含硒、碲藻蓝蛋白的形态分析、抗肿瘤作用及机理研究 (20771044)；
2.国家自然科学基金：新型有机硒化合物协同TRAIL诱导肿瘤细胞凋亡的分子机制研究 (21071062)；
3.国家自然科学基金：硒杂环化合物及其自组装膜的研究（20271022）；
4.广东省科技攻关项目：硒芳香环化合物作为临床抗肿瘤化疗药物增敏剂的研制与开发(2008A030201020)；
